More than 70 per cent of south-west Sydney's eligible population is now fully vaccinated against COVID-19 with NSW Health, general practices and pharmacies providing more than 1.3 million vaccinations across the region since the start of the national vaccination rollout in February.
More than 90 per cent of the eligible population in the seven south- west Sydney Local Government Areas have received their first dose of the vaccine.
South Western Sydney Local Health District chief executive Amanda Larkin said reaching the double dose milestone was an "incredible result".
"Thank you to everyone who has come forward to be vaccinated to protect themselves and their loved ones - this milestone could not have been achieved without you," Ms Larkin said.
"Our staff, GPs and pharmacies have been doing a wonderful job to provide the vaccine to the community and I am so proud of their outstanding work.
"I hope everyone enjoys the new freedoms from today but please continue to stay COVID-safe.''
Co-owner of Barone Pharmacy in Fairfield, pharmacist David Yassa, said the community's faith and trust in the advice of their healthcare professionals has been "amazing".
"And when you think about the barriers we face in South Western Sydney, like language barriers, it's an incredible effort," said Mr Yassa, who said it was still important for anyone not vaccinated to get the vaccine.
"People thought South Western Sydney was going to hold back the rest of Sydney but we were actually the front runners.
"We want life without COVID. For the safety of not only yourselves, but your families and the people around you, get vaccinated."
South Western Sydney Primary Health Network chief executive Dr Keith McDonald praised the workers on the frontline.
"When we needed them most at the end of June this year, our frontline vaccination workers rallied, helping with the smooth and swift rollout of vaccinations across our region," he said.
"Our GPs, practice nurses and support staff have so far administered 739,818 doses of vaccine to South Western Sydney residents - what an outstanding effort.
"We are continuing to actively work with practices to further ramp up their vaccinating capacity and have engaged some to also provide in-reach clinics and home visits to some of the most vulnerable people in our communities who otherwise have difficulty accessing usual services."